Frequencies of thalassemia in American blacks

Frequencies of thalassemia in American blacks.

The frequency of thalassemia was determined in a group of 541 healthy adult black males. Individuals with decreased mean corpuscular hemoglobin (MCH) values were evaluated further with hemoglobin analysis, iron studies, and globin chain synthesis. Of the males screened, 13.4% had MCH levels below 27.0 pg, while 1.4% had heterozygous beta thalassemia, 2.3% had iron deficiency, and 5.7% had globi...

Molecular Basis for Nondeletion a - Thalassemia in American Blacks a 2116 GAG -

An American black woman was found to have the phenotype of moderately severe a-thalassemia normally associated with the loss of two to three a-globin genes despite an a-gl9bin gene map that demonstrated the loss of only a single a-globin gene (-a/ aa). Several individuals in her kindred with normal a-globin gene mapping studies (aa/aa) had mild a-thalassemia hematologic values consistent with t...

Chronic Kidney Disease, Anxiety and Depression among American Blacks; Does Ethnicity Matter?

Introduction: Chronic kidney disease (CKD) is known to be associated with deterioration of mental health. However, it is clear that this link is over and beyond the effects of socio-economic factors and other medical conditions. This study had two aims: 1) to compare the association between CKD and general anxiety disorder (GAD) among the two major ethnic groups of American Bla...

Temporomandibular joint size decrease in American Blacks: evidence from Barbados.

A molecular basis for hemoglobin-H disease in American blacks.

We have applied gene counting and restriction endonuclease mapping techniques to the study of two American black families in which there were one or more cases of HbH disease. We found deletions of three of the four normal alpha-globin genes in individuals with HbH disease. In two of these individuals, the chromosome containing the single alpha gene could have originated by crossing over betwee...